Authorities said 75 gallons of diesel spilled on to the roadway near Long Beach Boulevard around 9:45 a.m. A hazmat team was called to access the scene and clean up.
All southbound lanes as well as the HOV and Nos. 1, 2 and 3 northbound lanes were shut down for an unknown duration, authorities said.
CHP tweeted around 12:30 p.m. that traffic was being diverted.
AIR7 was over the crash, where it appeared a big rig had lost its load, scattering large pipes across the middle of the freeway. Aerial footage showed traffic backed up for miles.
The cause of the crash is under investigation.