The violent two-car collision happened at 2:45 a.m. on the northbound side of the freeway, just south of Bellflower Boulevard, according to officials from the California Highway Patrol.
It appeared a truck slammed into another car and caught fire. At least one person died at the scene and it was not known whether anyone else was injured or hospitalized.
The identity of the victim was not released, and the cause of the crash remained under investigation, the CHP said.
Several lanes of the 405 North were shutdown overnight and reopened by 8 a.m.