The solo-vehicle crash happened about 6:40 a.m. on the southbound side of the 405, between Burbank Boulevard and the 101 Freeway interchange. The driver, a 51-year-old man, was transported to a hospital as a precaution, a CHP spokesman said.
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The transition road from the westbound 101 to the northbound 405 was also shut down as crews worked to transfer the highly flammable propane to another tanker.
According to a CHP incident log, the big rig slammed into the center divider, leaving chunks of concrete strewn across traffic lanes. Several vehicles sustained damage, including flat tires, due to the scattered debris.
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A caller reported that a fire erupted in the immediate aftermath of the crash, the Highway Patrol log said. However, a Los Angeles Fire Department spokesman later said no fire or fuel spill occurred.
Crews used three heavy-duty cranes to remove the tanker truck before the freeway was completely reopened shortly before 3 p.m., according to the California Highway Patrol.
The cause of the collision is under investigation.