The crash was reported shortly after 4:30 a.m. near Vermont Avenue, according to the California Highway Patrol.
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It was not immediately clear if the deceased person was an occupant of a vehicle or the pedestrian.
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The southbound HOV lane and all northbound lanes remained open throughout the morning, but traffic slowed to a crawl as crews worked to clear the scene.
Just after 8:30 a.m., Caltrans announced that all lanes were reopened.
The cause of the crash is under investigation.