The collision was reported around 4 a.m. on the interstate, just south of Lankershim Boulevard, according to the California Highway Patrol.
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The CHP issued a SigAlert for the closure of all lanes as crews worked to clean up the debris.
AIR7 HD captured traffic backed up until Hollywood Way. It's unclear if anyone was injured.
CHP opened two northbound lanes of the 5 Freeway around 6 a.m.
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No further details were immediately known.
City News Service Inc. contributed to this report