The crash, involving two big rigs and a passenger vehicle, was reported shortly before 5 a.m. near Grande Vista Avenue.
One man was extricated after being trapped in the wreck and was transported to a local trauma center in unknown condition, fire officials said. No other injuries were reported.
Traffic was snarled for miles even after crews were able to clear the scene at about 6 a.m.
The cause of the collision was not immediately known.