The collision occurred shortly before 3 a.m. on the southbound side of the freeway near Hyperion Avenue, according to the California Highway Patrol.
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The pedestrian, identified only as a 40-year-old woman, was crossing the southbound lanes on foot when she was struck by a 2019 Dodge Durango, the CHP said in a statement. After the collision, the driver remained at the scene and waited for emergency responders to arrive.
The pedestrian was pronounced dead at the scene, the news release said. No other injuries were reported.
A CHP spokesperson confirmed that a police vehicle was involved in the crash but did not specify which law enforcement agency.
"Alcohol or drugs has been ruled out as a factor for the driver of the Dodge Durango," the Highway Patrol statement said. "Alcohol or drug use by the pedestrian is still under investigation."
A SigAlert was issued and three southbound lanes were closed for over an hour as an investigation was conducted at the crash site, resulting in a backup of traffic even before the morning commute underway. All lanes were reopened by 4:30 a.m.
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Anyone who may have witnessed the collision or have information about the pedestrian is urged to call the Los Angeles Regional Traffic Management Center at (323) 259-3200.