The incident was reported around 3:40 a.m., according to traffic logs from the California Highway Patrol.
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All lanes of the southbound 5 Freeway past the 710 connector were shut down as crews worked to clear the scene and were reopened by 6:30 a.m., snarling traffic for drivers for a few hours.
Details on the pedestrian that was killed were not immediately available.
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DEVELOPING: This story will be updated as more information becomes available.