According to the California Highway Patrol's traffic log, the incident happened around 8 a.m. at Yorba Linda Boulevard.
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The big rig was going northbound when it crashed into the freeway's center divider, overturned and caught fire on southbound lanes.
Up to five vehicles were hit in the process, according to the CHP traffic log.
Nobody was killed, but it's unclear if anybody involved suffered any serious injuries.
By 11 a.m., the southbound side of the freeway remained completely shut down. At least two northbound lanes were also closed. An estimated reopening time was not available.
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DEVELOPING: We will add more details to this report as they become available.