The crash happened around 5 a.m. at Magnolia Avenue, according to the California Highway Patrol.
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Details about what led up to the crash were not immediately disclosed, but AIR7 HD was over the scene where a vehicle could be seen in an embankment just off freeway lanes.
The freeway closure created a massive traffic back-up for morning commuters as they were being diverted off the freeway at Pierce Street.
It's unknown when eastbound lanes would reopen.
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DEVELOPING: We will add more details to this report as they become available.