The fire started Wednesday afternoon at a commercial courtyard near the intersection of Baldwin Street and Bartlett Avenue, just east of Highway 395.
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The San Bernardino County Fire Department was the lead agency battling the fire with help from the Apple Valley Fire Protection District and the Victorville Fire Department.
A knockdown was reported around 8:27 p.m.
AIR7 HD captured video of the building engulfed in flames. Crews were also spotted trying to repair power lines, which also caught fire and caused a brief outage.
It's unclear what the building houses. The courtyard is located near several homes and a strip mall.
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Drivers and residents were urged to stay clear of the area.