The Ducks finished the regular season second in the Western Conference's Pacific Division, and the Sharks finished right below them in the division standings.
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San Jose had the upper hand in the regular season matchups against Anaheim, going 3-0-1.
The Ducks, who have home-ice advantage in the seven-game series, are hoping things go differently in the playoffs.
The Ducks have not won a Stanley Cup since 2007, their only title in franchise history.
In 2009, they beat the Sharks in their only playoff matchup against the franchise. The eighth-seeded Ducks upset the top-seeded Sharks in six games.
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In line with the team's motto, "Paint It Orange," the Ducks will paint over numbers posted around the arena for each win it earns.
They will have to paint a number 16 times to win a Stanley Cup.
Game one begins at 7:30 p.m. at the Honda Center.