The South Los Angeles shelter in particular is putting out the call for foster families, adopters and supplies.
With all six shelters at capacity, many dogs and cats are in danger of being euthanized if they don't find homes soon.
The agency is also urging pet owners to take advantage of the free and discount spay and neuter vouchers they offer to all LA city residents for cats, dogs, and rabbits.
For more information on how to help, visit www.laanimalservices.com.