The high-speed crash happened shortly before 1:30 p.m. at the intersection of 240th Street and Avenue O, in a remote area just east of Lake Los Angeles. One of the vehicles was believed to be traveling at 100 mph at the time of impact.
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One person was pronounced dead at the scene. That individual's identity was not immediately released.
Another person was airlifted by helicopter to a hospital after being trapped in the wreckage of one of the vehicles and extricated by firefighter-paramedics.
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The cause of the crash is under investigation by the California Highway Patrol.