It happened just before 9 p.m. near 136th Street East.
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According to the Los Angeles County Fire Department, the two paramedics were on their way to a house fire in the Lake Los Angeles area when they collided with a car.
The driver of the vehicle and the two paramedics were sent to Antelope Valley Hospital.
The paramedics suffered moderate injuries, though the condition of the driver injured is unclear.
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The crash is currently being investigated by the California Highway Patrol.
The cause of the collision is unknown.