The two-vehicle crash occurred at about 1:42 a.m., just north of the 60 Freeway interchange, and caused the tanker to overturn.
According to the California Highway Patrol, 60 gallons of diesel spilled onto the lanes.
It is unclear what caused the crash of if anyone was injured.
Crews spent hours addressing the hazmat situation at the scene and lifting the tanker upright before towing it from the scene.
The CHP canceled the Sigalert shortly before 8 a.m. and reopened all lanes.