Shortly before noon, Cal Fire and Riverside County firefighters responded to reports of an aircraft down at John and Hargrave streets.
The crash happened just west of the Banning Municipal Airport runway, authorities said.
The two occupants of the aircraft, described as a single-engine Cessna, suffered moderate injuries. They were evaluated by paramedics on scene, then transported to an area hospital for further treatment.
The California Highway Patrol shut down the eastbound 10 Freeway on-ramp at Hargrave Street.
The Federal Aviation Administration will investigate the cause of the crash.
City News Service contributed to this report.