The magnitude-3.7 earthquake was recorded about nine miles east of Barstow around 4 a.m., according to the U.S. Geological Survey.
No injuries or damage have been reported.
People in Trona, Buena Park and Fillmore reported feeling the quake, the USGS says.
It is unclear if the Barstow quake is one of the aftershocks felt in the region, including a magnitude 3.6 aftershock Tuesday morning near Ridgecrest.