Residents in the 17100 block of West Adlon Road were being warned to stay indoors and close all windows and doors after the bee swarm was reported at 3:47 p.m.
One man was brought to a local hospital with multiple bee stings.
A second person, a Los Angeles Police Department volunteer officer, was trying to swat away bees from his face as he walked down the street and at one point fell forward face down onto the asphalt.
As the bees continued swarming around his head and body, he tried to stand up but fell a second time. He remained conscious and sustained some cuts and bruises from the fall. Paramedics treated him at the scene and he was then transported to a local hospital for additional assistance.
LAPD volunteer stung dozens of times as bees swarm in Encino neighborhood
"One of our LAPD Volunteers assigned to West Valley Division sustained dozens of bee stings earlier today while assisting with a call for service," the LAPD later wrote on Twitter. "Fortunately he's in stable condition at a local hospital."
"Wishing him a speedy and full recovery. We thank him for volunteering to protect and serve. All of our LAPD volunteers are invaluable."
At least one other woman was stung multiple times and self-transported to a local hospital as a precaution.
A professional bee-removal contractor was called to the scene. The man wearing protective gear was working to remove a hive under the roof of a home in the area as hundreds of bees swarmed around him.
Some reports indicated there may have been thousands of bees involved in the swarm.