Shortly before 1 a.m., three or four masked and armed male robbers entered the house in the 1300 block of Casiano Road and ransacked it, an LAPD spokesperson said.
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A woman in her 60's and a man in his 70's were left bruised after being bound and punched.
The police spokesperson said a large amount of cash was stolen, but was unable to specify the amount.
Officers from the LAPD's West Los Angeles Division responded to the scene and conducted a search of the area, but the suspects remained at large. Detailed descriptions were not available.
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Police are scouring the neighborhood for any surveillance video of the attackers.