Investigators tell Eyewitness News the collision occurred around 8:15 p.m. at Doheny Drive and Clifton Way.
Investigators say a silver sedan was speeding when the driver lost control and slammed into a black SUV that was parked on Doheny Drive.
AIR7 HD was over the scene as officers were looking over the crash site. Two vehicles were left mangled in the middle of the street.
Police said two people were rushed to the hospital, though their condition is unknown.
Video showed officers with their guns drawn as they approached the scene of the crash.
One of the people transported to a hospital was handcuffed to a gurney as he was being loaded into an ambulance.