The jackknife crash was reported about 2:13 a.m. near Frazier Street, prompting the California Highway Patrol to issue a SigAlert. It was unclear if anyone was injured.
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Eastbound traffic slowed to a crawl in the HOV lane as crews used brooms and sand to clean up an apparent fuel spill at the scene.
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All lanes were reopened shortly after 5:30 a.m.
The cause of the incident is unknown.