Video from the protest captured the moment the vehicle hit the protester, who was on a bicycle.
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Footage also showed the pickup truck speeding off after it plowed through the crowd and hit the protester.
The victim was transported to a hospital with non-life threatening injuries.
Buffalo police are investigating and say that the driver is in custody.
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The protest in Buffalo came after a Kentucky grand jury brought no charges against Louisville police for Breonna Taylor's death.
The announcement sparked protests in multiple cities across the country.
RELATED: Grand jury indicts just 1 of the officers in Breonna Taylor case