Video from the protest captured the moment the vehicle hit the protester, who was on a bicycle.
Footage also showed the pickup truck speeding off after it plowed through the crowd and hit the protester.
The victim was transported to a hospital with non-life threatening injuries.
Buffalo police are investigating and say that the driver is in custody.
The protest in Buffalo came after a Kentucky grand jury brought no charges against Louisville police for Breonna Taylor's death.
The announcement sparked protests in multiple cities across the country.
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A Kentucky grand jury declined to indict any police officers for Breonna Taylor's death in March. One was charged with wanton endangerment to firing bullets that struck neighborhin