California Highway Patrol officials responded to the crash on the southbound side of the freeway at Burbank Boulevard around 3:30 a.m.
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Officials said they believe the semi-truck may have struck the center divider and right shoulder, leaving debris on all but one lane.
A SigAlert was in effect for three lanes and the Burbank Boulevard off-ramp. The alert was expected to remain in effect at least through 10 a.m.
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No injuries were reported in the wreck. The cause of the crash was under investigation.