SB 58 passed with a 41-11 vote on the assembly floor on Wednesday.
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State Sen. Scott Weiner authored the bill, which would allow people 21 years and older to possess and use small amounts of psychedelics.
The bill aims to decriminalize naturally occurring substances including psilocybin, psilocyn, dimethyltryptamine (DMT) and mescaline.
Mounting research suggests benefits of psychedelics as California considers legislation
Mounting research suggests benefits of psychedelics as California considers legislation
The bill requires for there to be more research and regulations around therapeutic use of the drug.
Proponents of the bill claim psychedelics can be used for monitored treatment for people struggling with addiction, PTSD, depression, anxiety, eating disorders and OCD.
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Opponents such as the Coalition for Psychedelic Safety and Education say they can cause hallucinations, paranoia and psychological trauma. It is urging state senators to block legislation until more safety measures can be put in place.
Critics also fear the measure does not include enough safeguards for minors.
Earlier this year, the bill passed the State Senate and was returned to the assembly floor for a final sign-off. It was then sent back to the Senate floor.
Newsom has until Oct. 14 to approve or veto the bill. If he approves the bill, the law will go into effect in 2025.