It happened at around 1:30 a.m. when two vehicles collided at the intersection of Terra Bella Street and Woodman Avenue.
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According to investigators, a power pole and a fire hydrant were sheered during the collision, causing water to flood the streets.
All four people - whose identities were not immediately released - were rushed to the hospital in serious condition. Details on the extent of their injuries were also not released.
It's unclear what led up to the crash.
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Authorities said the area will likely be closed as crews work to investigate the crash and fix the damaged pole and hydrant.
Anyone with information is urged to contact authorities.