The incident, which resulted in a fuel leak from the single-engine Piper PA32, was reported about 9:45 a.m. at Catalina Airport and prompted a response from Los Angeles County firefighter-paramedics, lifeguards and two air ambulances.
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All three of the injured were onboard the aircraft. Two of them were airlifted to hospitals.
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Ian Gregor, spokesman for the FAA's Pacific Division, said the incident happened after the plane landed.
The FAA and National Transportation Safety Board will investigate the cause of the crash.