The incident happened about 1 a.m. on the interstate, near Alondra Boulevard, according to the California Highway Patrol.
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The condition of the injured person was unknown.
Transition roads from the eastbound and westbound 91 Freeway to the northbound 605 were also temporarily closed as an investigation got underway.
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It was unclear if anyone was in custody in connection with the shooting.
All lanes and both transition roads were reopened shortly before 6 a.m.