The crash occurred shortly after 4:30 a.m. on the northbound side of the freeway, near University Parkway, according to a CHP incident log. All northbound lanes were temporarily closed as officers and firefighter-paramedics arrived at the scene.
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The two injured Highway Patrol officers were at the scene of an earlier three-vehicle crash when their patrol car was struck by an SUV, authorities said. One person was taken into custody.
The officers were transported to a medical center in unknown condition.
News video from the scene showed a mangled CHP sedan and an SUV with severe front-end damage.
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The cause of the collision is under investigation.