The event will close Hollywood and Santa Monica boulevards for a roughly 6.6-mile stretch, with only people-powered vehicles allowed between 9 a.m. and 4 p.m.
The open-streets festival is designed to reconnect residents with their neighbors and community, while supporting local businesses and encouraging healthy outdoor activities.
Two more similar events are planned this year -- on Oct. 9 in downtown Los Angeles and Dec. 4 in South Los Angeles.
CicLAvia officials have said more than 1.6 million people have taken part in the events over the years.
More information is available at www.ciclavia.org.
Sunday's events will formally begin with an 8:30 a.m. news conference on Santa Monica Boulevard featuring the mayors of Los Angeles and West Hollywood, along with other city, county and state officials.