It happened Tuesday around 5:25 p.m. in the 700 block of West Corregidor Street.
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When deputies from the Compton Sheriff's Station arrived on scene, they found the teen with a gunshot wound to his upper torso. He was rushed to the hospital where he later died.
The sheriff's department said a man was also found at the scene who had non-life threatening injuries.
"It's believed both victims were involved in a physical altercation when a male suspect opened fire on them," the sheriff's department said in a statement.
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Additional details regarding the suspect were not immediately available.
Anyone with information is urged to call the Los Angeles County Sheriff's Department's Homicide Bureau at 323-890-5500.