The event will be hosted by comedian Paul Rodriguez and will have performances by salsa legends Gilberto Santa Rosa and Jerry Rivera, among other artists.
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The iconic venue was established in 1999 and became L.A.'s hot spot for Latin music.
Big names in the entertainment industry, like Celia Cruz and Tito Puente, delighted patrons over the years.
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The Conga Room is closing after 25 years in business.