The wreck occurred shortly before 12:30 a.m. near the intersection of Santa Ana Avenue and Mesa Drive.
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One of the drivers, a 23-year-old man, died at the scene. Authorities identified the victim as Tustin resident Enrique Marquez.
Witnesses said the suspect ran a red light and slammed into Marquez's vehicle, sending it into a third vehicle.
Police arrested 24-year-old Kimberly Rene Martin, of Costa Mesa, on suspicion of drunk driving.
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The third driver was hospitalized with non-life-threatening injuries.
A man, who identified himself as the victim's uncle, left a lit candle at the intersection Tuesday afternoon.
The crash remains under investigation.