The crash occurred shortly after 9:30 a.m. in the 900 block of South San Pedro Street, near the L.A. Flower District, the Los Angeles Fire Department said. Several parked vehicles were also struck.
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The victims, a 14-year-old girl and a 50-year-old woman, had been waiting for a bus at the time of the collision, the Los Angeles Police Department said. Both were transported to a hospital.
The driver suffered an unspecified medical emergency before the crash and no crime was involved, according to the LAPD.
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Whether the driver was injured in the collision was unclear.