Paramedics and firefighters responded to the area of Florence Avenue and Market Street at 2:30 a.m.
First responders found the mangled wreckage of a Honda Accord after it slammed into a tree.
The 22-year old male driver was pronounced dead at the scene.
Four passengers were transported to the hospital with varying injuries.
Witnesses said the car was speeding, ran a red light and that the driver lost control of the vehicle leading to the crash.
It was unknown if alcohol or drugs played a factor in the crash.
Anyone with information regarding the accident is asked to call Inglewood Police Traffic (310) 412-5134 or the 24-hour anonymous hotline number at 888-41-CRIME (888-412-7463).