The violent crash occurred shortly before 5:30 a.m. at Vermont Avenue and Century Boulevard, according to the Los Angeles Fire Department.
Kimberly Izquierdo, 27, Veronica Amezola, 23, and Juvelyn Arroyo, 23, were pronounced dead at the scene.
Thee survivors were rushed to a medical center, two of them in critical condition. The condition of the third patient was unknown.
According to Los Angeles police investigators, a solo driver in a white Mercedes-Benz was traveling at high speed when it ran through the red light and crashed into a Honda occupied by a driver and four passengers.
One person was ejected from the Honda, the LAPD said. The three deceased female victims were occupants of that vehicle.
"It almost hit me too," said Victor Gonzalez, who witnessed the crash. "I starting shaking them, I started talking to them, waking them up, they weren't responding. They weren't breathing. It's crazy."
One of the two vehicles was an Uber rideshare vehicle, but it was unclear which one, an LAPD spokesperson told ABC7.