The actor's online estate sale features more than 300 eclectic items from an antique barber's chair to a vintage jukebox.
The sale benefits The People Concern, which works on homelessness and other issues in the Los Angeles area.
Arquette is also starring in a new movie, "Amanda and Jack Go Glamping" which is available in theaters and on-demand Nov. 10.
To see Arquette's full conversation with George Pennacchio, watch the video above.