The crash occurred at Burbank Boulevard near Hayvenhurst Avenue at about 7:20 p.m.
The red Lamborghini was going eastbound at a high rate of speed and collided with a gray Jeep Cherokee making a left turn, causing the Lamborghini to break into two pieces after hitting a tree, police said.
Both people in the Lamborghini -- a 25-year-old male and a 19-year-old female -- died due to the crash.