Authorities responded to the traffic collision involving two vehicles at 175th Street East shortly before 7 p.m.
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Two victims, a man approximately 25 years old and a woman in her 40s, were killed at the scene, and two children were transported by helicopter to area hospitals with major injuries, CHP officials said.
A SigAlert was issued that temporarily shut down all directions of SR-138. As of 10:45 p.m., one lane was back open on the westbound side while all eastbound lanes remained blocked until further notice.
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No further information was released.