The man was transported to a local hospital and several hours later deputies announced he had died.
Los Angeles County deputies were called to the home in the 3800 block of Bullis Road around 12:30 p.m. Tuesday.
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There was a report of a family dispute and a man threatening other family members with a hammer.
He was believed to be under the influence of drugs or alcohol.
About five deputies responded to the home and in the ensuing confrontation, shot him.
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No deputies or others at the scene were injured.
The man was transported to a local hospital. By early evening, officials said he had been pronounced dead.