It is believed that the alleged gunman is among the dead.
Officers responded about 12:45 a.m. to a report of gunshots in the 8100 block of Leeds Street, the Downey Police Department said in a news release. The scene was in a neighborhood comprised of single-family homes.
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The officers arrived to find five people, identified only as four men and a woman, who had been shot, the statement said. Three men were pronounced dead at the scene.
The surviving man and woman were transported to a hospital in unknown condition, authorities said.
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The circumstances that prompted the shooting were unknown, but the news release said a preliminary investigation "revealed this incident was isolated and there are currently no outstanding suspects."