The blaze at the three-story building on E. 4th and San Pedro streets was reported around 1:06 p.m., according to the Los Angeles Fire Department.
AIR7 HD was over the scene as thick black smoke billowed from the structure, which could be seen from miles away. The fire involved dense storage on the third floor, the fire department said.
The cause of the fire remains under investigation.
No injuries have been reported.