The fire broke out at a two-story building at 1325 S. Los Angeles St. It's believed to be a shop in the area.
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ABC7 cameras captured smoke coming out of the building for at least two hours Sunday morning.
Crews were finally able to get the fire under control and out shortly before 7 a.m.
Firefighters stayed through the morning as they worked to track down smoldering areas while working around debris caused by the partial roof collapse.
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It's unclear what prompted the fire and no injuries were reported.