Investigators tell Eyewitness News they received a call about a shooting at the hotel just before 5 a.m. Tuesday.
The victim, who is believed to be about 20 years old, was pronounced dead at the scene.
Police said the suspects fled in a white SUV, though details regarding an exact make and model were not immediately released.
A description of the suspects was also not immediately available.
On Tuesday morning, the area surrounding the hotel's entrance was blocked off as police conducted its investigation.
A white Rolls-Royce car was seen outside of the hotel getting towed around 9:30 a.m. and appears to be part of the investigation.
Meanwhile, LAPD says it's investigating the incident as a homicide.
Eyewitness News reached out to the JW Marriott for an interview but did not hear back.
Anyone with information is urged to contact police.