The operation seized 44 pounds of meth, 128 pounds of cocaine, and six and a half pounds of fentanyl.
Total value: more than $1 million.
Agents also seized guns and $300,000 in cash.
A federal grand jury indicted seven members of the drug crew.
Four were arrested this week. Sarkis "Sam" Kyurkchian, 40, of North Hollywood is a fugitive on the run.