The man, whose name and age weren't released, reportedly died of "severe pulmonary injury." Additional information on the death has not yet been released.
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It is now the second vaping-related death in California and the seventh in the United States.
"It seems that any vaping is a risk," said Tulare County Public Health Officer Dr. Karen Haught.
Health officials reported 63 cases of respiratory illnesses across the state associated with vaping THC or cannabis oils. Many of those affecting the lungs.
"A severe respiratory distress, difficulty breathing, pain, fever," Haught said.
Haught says many e-cigarette users nationwide have reported similar symptoms. This includes shortens of breath, chest pains, nausea and vomiting.
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According to Haught, what's most alarming is health officials don't know the long-term effects.
"We don't know enough information to know what its effects are and we know there are some conditions right now that are occurring in association with it," she said.
The Centers for Disease Control and Prevention has activated its emergency operations center to look into what's causing hundreds of cases of serious breathing illnesses in people who use e-cigarettes or other vaping devices.
The dangers of vaping also prompted Gov. Gavin Newsom to sign an executive order Monday, announcing $20 million will go towards a vaping awareness campaign.
Warning labels will be required on e-cigarette ads and at stores. Authorities are also cracking down on illegal vaping products.
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"A governor alone is not afforded the right, legally to ban these products outright, that we would need legislative support. Again, we're pushing the envelope. We'll see how far we can go," Newsom said in a press conference.
Haught hopes theses new measures are effective.
"I think we should be doing our best to discourage from people starting to vape or continuing to vape," she said.
In addition to the executive order, Newsom is also exploring an e-cigarette tax based on products with nicotine content.