The wreck was reported shortly before 1:30 p.m. near the Irwindale Avenue exit, authorities said.
A crash, which involved a big rig ending up on its side, shut down all eastbound lanes of the 210 Freeway. Lanes began reopening shortly after 3 p.m.
A total of four people were injured -- three people suffered minor injuries and one person was transported to an area hospital.
The cause of the crash was not immediately known.