A tweet from Erica Garner's official Twitter account said: "She passed away this morning. The reports are real. We didn't deserve her."
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She had suffered major brain damage from a massive heart attack on Christmas Eve.
Her mother, Esaw Snipes-Garner, said her daughter went into cardiac arrest during an asthma attack and had since been in a coma.
Snipes-Garner says her daughter suffered her first heart attack not long after giving birth to a baby boy in August. Doctors said the pregnancy had put a strain on her heart, which was later found to be enlarged.
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Eric Garner died after a police officer subdued him with a chokehold in 2014. His last words were "I can't breathe," which became a slogan for activists.
Erica Garner appeared in campaign commercials for Sen. Bernie Sanders during his 2016 presidential run.