Los Angeles police said two people on a stolen 2004 Suzuki motorcycle crashed near the intersection of 62nd Street and Grammercy Place after a chase began at about 8 p.m.
Officers were at first following the motorcycle and then initiated a pursuit after the driver did not pull over, according to police.
One suspect died at the scene. The other suspect was critically hurt and was transported to a hospital, where he later succumbed to his injuries.
It was not immediately known where the chase began.
No other injuries were reported.